Before taking any medication ..

A drug eruption is an adverse drug reaction of the skin. Most drug-induced cutaneous reactions are mild and disappear when the offending drug is withdrawn. Drugs can also cause hair and nail changes, affect the mucous membranes, or cause itching without outward skin changes
Although most drug eruptions are exanthematous, different types of drug eruptions are described ...

diagnosed mainly from the medical history and clinical examination. However, they can mimic a wide range of other conditions, thus delaying diagnosis (for example, in drug-induced lupus erythematosus, or the acne-like rash caused by erlotinib). A skin biopsy, blood tests or immunological tests can also be useful. If the causative agent can not be withdrawn, the symptoms should be relieved as much as possible.

Rates of reactions to commonly used drugs are as follows:

• Amoxicillin - 5.1%
• Trimethoprim sulfamethoxazole - 4.7%
• Ampicillin - 4.2%
• Semisynthetic penicillin - 2.9%
• Blood (whole human) - 2.8%
• Penicillin G - 1.6%
• Cephalosporins - 1.3%
• Quinidine - 1.2%
• Gentamicin sulfate - 1%
• Packed red blood cells - 0.8%
• Mercurial diuretics - 0.9%
• Heparin - 0.7%

Cutaneous reaction rates in patients with HIV infection are as follows :

• Sulfasalazine - 20%
• Trimethoprim-sulfamethoxazole - 14.9%
• Dapsone - 3.1%
• Aminopenicillins - 9.3%
• Penicillins - 3.8%
• Anticonvulsants - 3.4%
• Penicillinase-resistant penicillins - 2.9%
• Cephalosporins - 2.7%
• Quinolones - 2.1%
• Ketoconazole - 2%
• Clindamycin - 1.8%
• Primaquine - 1.8%
• Tetracycline - 1.2%
• Pentamidine - 1%
• NSAIDs - 0.9%
• Erythromycin - 0.6%
• Zidovudine - 0.3%

Drugs that commonly cause serious reactions are as follows:

• Allopurinol
• Anticonvulsants
• NSAIDs
• Sulfa drugs
• Bumetanide
• Captopril
• Furosemide
• Penicillamine
• Piroxicam
• Thiazide diuretics

Drugs unlikely to cause skin reactions are as follows:

• Digoxin
• Meperidine
• Acetaminophen
• Diphenhydramine hydrochloride
• Aspirin
• Aminophylline
• Prochlorperazine
• Ferrous sulfate
• Prednisone
• Codeine
• Tetracycline
• Morphine
• Regular insulin
• Warfarin
• Folic acid
• Methyldopa
• Chlorpromazine
• Serotonin-specific reuptake inhibitors
• Topical gels (eg, 4% tetracaine gel may cause serious cutaneous adverse reactions)

^{source : emedicine , wikipedia}

Too much skin ! part 2

Here is a continuation for the previouse blog ( Too much skin ! part 1)

 these are a list of conditions that I joined togather because they have one thing in commen .. too much skin .. and below each condition a video related to the condition .

c) Diffuse hereditary palmoplantar keratodermas 

        is an autosomal dominant disorder in which hyperkeratosis is confined to the palms and soles, usually evident at birth or in the first few months of life.the they present in early childhood with redness of the palms and soles. The palms and soles gradually become thicker and develop a yellowish, waxy appearance. There is a clear cut-off between affected and unaffected skin and the edge of the thickening is often red. This is usually obvious by the age of 3 to 4

here is a shocking viedo on a man possibly having this condition .

Shocking story of Half Man Half Tree .. http://www.youtube.com/watch?v=eJLG85gn0bc

D) plaque psoriasis

skin rapidly accumulates at these sites, which gives it a silvery-white appearance. Plaques frequently occur on the skin of the elbows  and knee , but can affect any area, including the scalp palms of hands and soles of feet, and genitals .Psoriasis is not contagious and can be inherited. Environmental factors such as smoking, sun exposure, alcoholism , and HIV infection  may affect how often the psoriasis occurs and how long the flare-ups last

here is a video showing the suffering of psoriasis patients

http://www.youtube.com/watch?v=5fVVRvtoUyU

I wish for all the people world-wide to be healthy and happy

my references : wikipedia ,dermNet,webmd,emedicine

Too much skin ! part 1

these are a list of conditions that I joined togather because they have one thing in commen .. too much skin .. and below each condition a video related to the condition 

Here's a list of this conditions with a small comment on each : 

a)  Harlequin type ichthyosis

is the most severe form of congenital ichthyosis, characterized by a thickening of the keratin layer in fetal  human skin. In sufferers of the disease, the skin contains massive, diamond-shaped scales, and tends to have a reddish color. In addition, the eye , ears , penis , and the appendages may be abnormally contracted. The scaly keratin greatly limits the child's movement. Because of resultant cracked skin in locations where normal skin would fold, it is easily pregnable by bacteria and other contaminates, resulting in serious risk of fatal infection.

• Interesting real life story on this condition on youtube :

Extraordinary People - The Girls With Too Much Skin http://www.youtube.com/watch?v=hGHDjiinh80

B) Ehlers–Danlos syndrome - Dermatosparaxis

very rare, with about 10 cases reported. The dermatosparaxis type is characterised by extremely fragile and sagging skin. The skin sags and wrinkles, and extra (redundant) folds of skin may be present as children get older. Joints are very loose, which can delay the development of motor skills such as sitting, standing, and walking. Infants with the condition are born with a hernia around the belly-button. Other symptoms include a small chin, a blue tinge to the sclera, and mild overgrowth of body hair.

Could this gentleman have dermatosparaxis type of Ehles-danlos syndrome ( he stretched his skin up to 14.2 cm away from his body!) :

Stretchiest skin - Guinness World Record

http://www.youtube.com/watch?v=f46SpiboAew&NR=1&feature=fvwp